Model: Skin, arterial, and lens tissue from donors between the ages of 20 and 25 and also 75 
Dosage: 5 µM solution of CMLase, incubated overnight

Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

An engineered enzyme reverses age-related protein damage that researchers have long thought irreversible in human eye, skin, and artery tissues.

(A bioengineered enzyme [purple structure] cleaves a prevalent type of AGE [brown glob] on protein residues that are part of protein filaments [dull green chains] | The Scientist)

A bioengineered enzyme reverses age-related protein damage, long thought of as irreversible damage, in human lens, skin, and artery tissues.

Basic Research

Model: Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.
Dosage: Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of Kluyveromyces fragilis yeast extract, 350 mg of Saccharomyces cerevisiae yeast extract, or a placebo.

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Joe Rogan’s Top Supplements for 2026

Joe Rogan’s latest supplement stack includes compounds targeting longevity, cognition, immunity, fitness, and optimal hormone levels.

(Joe Rogan on set for his podcast | Spotify Newsroom)

Joe Rogan’s updated supplement stack for 2026 includes compounds targeting longevity, cognition, immunity, fitness, and optimal hormone levels.

Aging &amp; Longevity

Model: Female ICR (Institute of Cancer Research) mice
Dosage: ~240 mg/day of pterostilbene within food

Pterostilbene Promotes Fertility in Aged Females

The plant-based antioxidant, pterostilbene, improves egg quality in aged mice, as measured by an increase in live offspring. 

Blueberries are among the richest natural sources of pterostilbene. 

Search Result: quality of life

New Research: Bioengineered Enzyme Shows Ability to Reverse Molecular Aging in Human Tissue

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Rapamycin and Exercise: New Study Finds Potential Performance Decline

Joe Rogan’s Top Supplements for 2026

Pterostilbene and Fertility: New Study on Restoring Reproductive Aging