<p><span style="font-weight: 400;">Model: Aged C57B/6 mice (between 18-25 months old) </span></p>
<p><span style="font-weight: 400;">Dosage: 5 mg/kg/day of ABT-263 was fed to mice while 50 mg/kg/day of dichloroacetate and metformin were injected. For lifespan, they were administered for five consecutive days, followed by a two-day intermission, then an additional five consecutive days, followed by a 6-week intermission.</span></p>


The combination of dichloroacetate, metformin, and ABT-263 eliminates cancer cells and age-promoting senescent cells while improving endurance and extending lifespan in mice. 


The study was led by Dr. Irina Conboy (image: berkeley.edu). 

Aging &amp; Longevity

<p><span style="font-weight: 400;">Model: Male Wistar rats </span></p>
<p><span style="font-weight: 400;">Dosage: 1.5 g/kg/day of orally administered glycine for 5 months </span></p>


Glycine, an amino acid shown to extend the lifespan of mice, moderately extends the lifespan of flies and counters brain and muscle degeneration in aged rats. 

<p><span style="font-weight: 400;">Model: C57BL/6J mice </span></p>
<p><span style="font-weight: 400;">Dosage: Eating only within an 8-hour window and fasting for 16 hours (~20% caloric deficit may be required) </span></p>


Restricting food intake for 16 hours a day improves the health of female mice and moderately prolongs the life of male mice. 

The principal investigators of the study (from left to right): Dr. Carla Green, Dr. Victoria Acosta-Rodriguez, and Dr. Joseph Takahashi (image: dallasnews.com). 

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


<p>Model: Six adults who received intravenous NAD+ and eight adults who received intravenous NR</p>
<p>Dosage: 500 mg of intravenous NAD+ or 500 mg of intravenous NR daily for four consecutive days</p>


Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

A Stanford study supports the short-term safety of NAD+ and NR infusion therapies, and participants who received NR infusions exhibited significantly lower HbA1c (a blood test that reflects average blood sugar over two to three months).

(An IV bag containing a solution with NAD+ | Crete Fertility Centre)

A Stanford human trial provides the first data supporting the safety of NAD+ IV and NR IV therapies.

Search Result: metabolic aging

Drug Combo Targets Cancer and Senescent Cells to Prolong the Lifespan of Mice, New Study Shows

Glycine Extends Life & Counters Brain and Muscle Degeneration, New Study Shows

16-Hour Intermittent Fasting Improves Health and Longevity, New Study Confirms

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions