Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Brain &amp; Neurons

<p>Participants: Older adults (ages 60 to 80) with mild cognitive impairment  </p>
<p>Dosage: 320 mg/day of anthocyanin capsules for 24 weeks </p>


Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

Aging Guru Bryan Johnson’s Supplement List for 2026

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

(Bryan Johnson, who utilizes a continuously updated protocol to slow aging and optimize his body | Netflix)

Changes to Bryan Johnson’s updated 2026 supplement stack include taking NMN or NR six days a week instead of seven and removing rapamycin.

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Search Result: chronic stress

Top Evidence-Based Interventions to Lower Biological Age

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

Aging Guru Bryan Johnson’s Supplement List for 2026

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age