Model: C57BL/6J Mice
Dosage: 20 ug of sEVs’ protein on days 1 and 14 of experiment

Particles Secreted from Stem Cells Reduce Frailty and Inflammation 

University of Valencia researchers use small vesicles (sEVs) derived from young stem cells (ADSC) to reduce frailty, regulate inflammation, and lower senescence - a critical dormant state of cell-cycle arrest that drives aging. 


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sEVs Senior Author

Senior author, Dr. Consuelo Borras | INCLIVA

Longevity

Model: female ICR-CD1 mice
Dosage (oral): 2 x 10^8 cfu/100µL AKK daily for one month

Spanish scientists find that a probiotic prolongs lifespan, rejuvenates strength and coordination, and improves the immune system of old mice. 

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probiotic

Electron microscope image of probiotic (AKK) | Derrien et al., 2017

C57BL/6J mice (16 male; 16 female)
Diet supplemented with glycine and N-acetylcysteine (protein 23.5%, 3.0 kcal/g feed, Nacetylcysteine (NAC) 1.6 mg/g feed and glycine 1.6 mg/g feed

Antioxidant Cocktail Increases Lifespan and Attenuates Aging Hallmarks

Researchers from Baylor College show that glycine and N-acetylcysteine (GlyNAC) significantly increases mouse lifespan and improves multiple aging hallmarks. 


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Houston,,Texas,,Usa,-,March,9,,2022:,Closeup,Of,Baylor

Model: Prematurely aged (progeria) mice
Dosage: Tail vein injection of mTERT (mouse telomerase) lentiviral constructs

Using a therapy that extends telomeres — the DNA at the ends of our chromosomes, scientists reduce senescence in human cells and significantly prolong the lifespan of mice. 


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Senior author, Dr. John Cooke with research team | Credit: Daniel Kramer, Houstonia 

Model: Genetically diverse UMHET3 mice bred from CByB6F1/J female mice and C3D2F1/J male mice (monitored first 45 days of life). 
Dosage: Chow containing encapsulated rapamycin (42 ppm of active compound) for 45 days.

Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

Scientists find that treating mice with rapamycin early in life moderately increases lifespan and improves physical fitness at the expense of inhibiting growth in mice. 


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EL rap picture

Author, Dr. Leonid Peshkin | Longevity.Technology 

Model: Sprague Dawley rats
Dosage (oral): 0.1 mg/kg chloroquine

Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Chinese researchers show that the anti-malaria drug chloroquine moderately extends the lifespan and rejuvenates the organs of elderly rats.

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Structural,Chemical,Formula,Of,Chloroquine,Molecule,With,Pills,And,Tablets.

Embryo with Beating Heart Grown in Lab

Israeli scientists successfully grow embryos with functioning hearts in a test tube using mouse embryonic stem cells. 


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Picture0

Senior author, Dr. Jacob H. Hanna holding synthetic embryos | eNCA, AFP/Ahmad Gharabli 

Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease 

Researchers in France moderately prolong the lifespan of mice and reverse skin, bone, lung, and kidney aging with cellular reprogramming — a new technology that rejuvenates cells.  

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Corresponding author, Dr. Jean-Marc Lemaitre | franceinfo

Model: male C57BL/6 mice
Dosage (oral): 5 mg/kg dasatinib plus quercetin or 50 mg/kg ABT263

Old Blood Induces Aging in Young Mice by Spreading Senescence

By transferring blood from old to young mice, Buck scientists show that young mice exhibit increased levels of senescent (aged) cells and of age-related muscle, liver, and kidney disease markers. 


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Corresponding author, Judith Campisi, Ph.D. | Buck Institute for Research on Aging 

C57BL/6 Mice: 3-month-old, 21-month-old
Hesperetin: 100 mg/kg/day (oral)
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New Longevity Molecule Prolongs Lifespan and Delays Cardiac and Muscle Aging 

Taiwanese researchers show that hesperetin, a compound found in many citrus plants, moderately prolongs lifespan in naturally aging mice and delays features of cardiac and skeletal muscle aging. 


New Study Shows Particles Secreted from Stem Cells Reduce Frailty and Inflammation

Scientists Find Probiotic Improves Longevity of Mice

Baylor College Scientists Increase Lifespan and Attenuate Aging Hallmarks with Antioxidant Cocktail

Scientists Prolong Mouse Lifespan by Extending Telomeres

Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

Study Shows Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Israeli Researchers Grow Embryo with Beating Heart in Breakthrough Study

French Scientists Show Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease

Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence

New Longevity Molecule found to Prolong Lifespan and Delay Cardiac and Muscle Aging