Model: Human (middle age)
Dose: Calorie restriction (25%)

Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults

A first-of-its-kind clinical study from Columbia University's Mailman School of Public Health found that two years of calorie restriction slowed the human aging process.

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New,York,,Usa,-,July,13,,2016:,Life,In,Columbia

Longevity Interventions for Age-related DNA Changes

Epigenetics – changes to DNA expression rather than alteration of the DNA itself – may be the new frontier for anti-aging interventions, with researchers and doctors uncovering the ways in which epigenetics regulate age-related diseases and developing therapies to target these epigenetic changes.


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Dna,Double,Helix,Illustration.,Human,Dna,Spiral,Formed,From,Nucleotide

Model: C57BL/6J mice
Dosage: 1 mg/mL for a total of 3 mL daily of abacavir dissolved in drinking water for six months

Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging

Latent viral sequences in DNA have evolved with mutations to render them inactive, yet the most recently inherited of these lack suppression, and their activity drives aging.

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RVLPs

(Transmission electron microscopy images of young human cells treated with medium from young cells [top] and senescent cells [bottom]. The cell on the bottom treated with senescent cell medium exhibits a dark circle that is a retrovirus-like protein.)

Viral sequences inserted into DNA during ancient viral infections can become activated as we get older, driving cellular senescence and aging.

Model: SIRT6-defecient 129Sv mice 
Dosage: High-fat diet consisting of 16% carbohydrates, 19% protein, and 65% fat (from mostly coconut oil)

A high-fat diet significantly increases the lifespan of prematurely aged mice, restoring their blood glucose levels, reducing the spread of harmful bacteria, and reducing markers of aging. 


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main

Compared to normal mice (left), mice fed gut bacteria from short-lived mice display features of aging, such as gray hair (right). 

Sirtuins, Lifespan Extension, and Aging

Sirtuins are a family of seven enzymes found in every cell that participate in several critical biological processes known to counter aging, like cellular energy optimization and DNA repair.

sirtuin

Basic Research

Nature Aging study reveals light-dependent technique to more accurately eliminate senescent age-associated cells and counter signs of brain, muscle, kidney, and liver aging in old mice. 

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Light-Sensitive Smart Senolytic KSL0608-Se 

Model: C57BL/6J mice 
Dosage: 300 mg/kg of alpelisib in food beginning at 12 months of age until death

The Nature Aging study supports the need for clinical tests of how adding alpesilib to diets affects longevity and aging.

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JGinsulinmain

Lead author, Dr. Chris Hedges | University of Auckland 

Northwestern University Study Shows Pro-Longevity Molecules Reverse Age-Associated Transcription Deficiency

In multiple species, longer strands of mRNA have lower abundance with age, but pro-longevity molecules counter this effect.

amaral

Amaral

(The study’s Principal Investigator Luis A.N. Amaral, PhD | Flickr.com)

Gene activity declines for longer genes and increases for shorter genes, which reduces the abundance of pro-longevity proteins and increases anti-longevity proteins with age.

Model: Male C57BL/6 mice
Dosage: 10 µg/day MR409 injected subcutaneously for 4 months beginning in old age

By restoring growth hormone secretion with a peptide (tiny protein) called MR409, researchers improve old mice's physical activity, hair growth, and heart function while increasing survival. 


andrewschally

Andrew Schally in the lab

Author and Nobel Laureate, Dr. Andrew V. Schally | Miami VA Healthcare System 

Model: C57BL/6J Mice
Dosage: 20 ug of sEVs’ protein on days 1 and 14 of experiment

Particles Secreted from Stem Cells Significantly Reduce Aging

University of Valencia researchers use small vesicles (sEVs) derived from young stem cells (ADSC) to reduce frailty, regulate inflammation, and lower senescence - a critical dormant state of cell-cycle arrest that drives aging. 


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sEVs Senior Author

Senior author, Dr. Consuelo Borras | INCLIVA

Clinical Study Shows Calorie Restriction Slows Pace of Aging in Healthy Adults

Longevity Interventions for Age-Related DNA Changes

Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging

New Study Suggests Plant Fat Could Counter Aging by Reducing Harmful Bacteria from Gut

Sirtuins, NAD+, Lifespan Extension, and Aging

Researchers Counteract Liver, Kidney, and Muscle Aging with Light-Activated “Smart” Senolytic

FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%

Northwestern University Study Shows Longevity-Promoting Molecules Reverse Aging-Associated Transcription Deficiency

Scientists Reduce Multiple Effects of Aging with Growth Hormone Stimulator

New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging