Model: male C57BL/6 mice
Dosage (oral): 5 mg/kg dasatinib plus quercetin or 50 mg/kg ABT263

Old Blood Induces Aging in Young Mice by Spreading Senescence

By transferring blood from old to young mice, Buck scientists show that young mice exhibit increased levels of senescent (aged) cells and markers of age-related muscle, liver, and kidney disease. 


campisi

Corresponding author, Judith Campisi, Ph.D. | Buck Institute for Research on Aging 

Longevity

C57BL/6 Mice: 3-month-old, 21-month-old
Hesperetin: 100 mg/kg/day
&nbsp;

New Longevity Molecule Prolongs Lifespan and Delays Cardiac and Muscle Aging 

Taiwanese researchers show that hesperetin, a compound found in many citrus plants, moderately prolongs lifespan in naturally aging mice and delays features of cardiac and skeletal muscle aging. 


hespertin-2

hespertin

Synovial Mesenchymal Stem Cells (MSCs) acquired from 5 osteoarthritis patients (age range: 71-80 years)
ABT-263: 20 µM

Researchers Treat Arthritis Using Senolytic ABT-263

Researchers from Tokyo Medical and Dental University utilize the senolytic drug ABT-263 to enhance the function of bone joint stem cells taken from patients with arthritis (osteoarthritis). 


tokyojapan-2february2022exteriorviewoftokyomedical

Tokyo,,Japan,-,2,February,2022?exterior,View,Of,Tokyo,Medical

C57BL/6 Mice
Low-protein diet ad libitum

Study Shows Low-Protein Diet Can Extend Lifespan

Researchers from the Pennington Biomedical Research Center in Louisiana demonstrate that Fgf21 is needed to adopt the health benefits of a low-protein diet. 

pennington-center

Pennington Center

New Nasal Spray Gene Therapy Increases Lifespan by 40% 

Researchers from Rutgers New Jersey Medical School utilize gene therapy to increase the activity of genes - telomerase reverse transcriptase (TERT) and follistatin (FST) - known to contribute to increased lifespan (TERT) and muscle development (FST). 

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New,Brunswick,,Nj,-,November,2,,2018:,Rutgers,University,Logo

Time-Restricted Feeding Enhances Caloric Restriction 

While caloric restriction alone increases lifespan by 10%, caloric restriction within a 2-hour feeding window at night increases the lifespan of mice by 35%.  


hungrywomaneatingasandwichatnightinthekitchen

Hungry,Woman,Eating,A,Sandwich,At,Night,In,The,Kitchen.

Study shows that age-related changes in teste cells, including increased inflammation impairs sperm cell development in obese older males.


spermmicroscopicviewrealmaterialimage

Sperm,Microscopic,View,,Real,Material,Image

(Lukasz Pawel Szczepanski | shutterstock)

Medicinal Mushroom Restores Age-Related Physical Decline 

Italian researchers find that treating aged mice with Lion’s Mane (H. Erinaceus primordium) extract  boosts physical performance and improves neural oxidative stress.


lions-mane-mushroom

A brief description of NAD+ intravenous therapy and the research behind it.   


vitamintherapyivdripinfusioninmanblood

Vitamin,Therapy,Iv,Drip,Infusion,In,Man,Blood

Regular Ginseng Use Reduces Mortality Among Chinese Women

A study of over 56,000 women in China indicates that regular ginseng use could reduce all-cause mortality and mortality due to cardiovascular disease.


Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence

New Longevity Molecule found to Prolong Lifespan and Delay Cardiac and Muscle Aging

The Senolytic ABT-263 Enhances Stem Cell Function to Improve Osteoarthritis

The Hormone FGF21 can Extend Lifespan through Low-Protein Diet

New Intranasal and Injectable Gene Therapy Prolongs Lifespan by 40%

Study Shows Time-Restricted Feeding Enhances Longevity Benefits of Caloric Restriction in Mice

Obesity Associated with Impaired Sperm Cell Development in Older Males

Study Shows Lion’s Mane Restores Physical Performance in Aged Mice

Does NAD+ IV “Drip” Therapy Work?

Regular Ginseng Use Linked to Reduced Mortality Among Chinese Women